{"id":93252,"date":"2025-05-28T17:17:14","date_gmt":"2025-05-28T15:17:14","guid":{"rendered":"https:\/\/runlovers.it\/?p=93252"},"modified":"2025-05-27T10:37:51","modified_gmt":"2025-05-27T08:37:51","slug":"marathon-and-mind-the-hidden-secret-between-neurons","status":"publish","type":"post","link":"https:\/\/runlovers.it\/en\/2025\/marathon-and-mind-the-hidden-secret-between-neurons\/","title":{"rendered":"Marathon and Mind: The Hidden Secret Between Neurons"},"content":{"rendered":"<p class=\"p1\">Every so often, when your legs start to ache and the miles pile up, you\u2019ve probably found yourself wondering how on earth you\u2019re supposed to make it to the finish line\u2014maybe after hours of running, with your energy reserves completely drained and your mind still sharp.<\/p>\n<p class=\"p1\">Carlos Matute is a neuroscientist. The kind who usually spends more time in the lab than on a running track. And yet, it was while running\u2014during one of those long training sessions where your thoughts turn to liquid and your sense of self dissolves into the rhythmic beat of your shoes on the pavement\u2014that he asked himself a seemingly simple question: how do we stay conscious all the way to the finish line when our energy is completely depleted?<\/p>\n<p class=\"p1\">From there, Matute did what any curious scientist does when they stumble onto a good question: he searched for an answer. And he found it in the most unexpected place of all\u2014brain fat.<\/p>\n<p class=\"p1\">As <a href=\"https:\/\/www.nationalgeographic.com\/health\/article\/marathon-running-brain-myelin?\"><i>National Geographic<\/i> reports<\/a>, in <a href=\"https:\/\/www.nature.com\/articles\/s42255-025-01244-7\">his study<\/a> published in <i>Nature Metabolism<\/i>, Matute and his team showed that during extreme physical exertion\u2014like running a marathon\u2014the brain starts using its own myelin sheaths as fuel. These are the fatty layers that protect and insulate neurons. In essence, the brain feeds itself, temporarily sacrificing part of its own structure to stay alert.<\/p>\n<h3 class=\"p3\">The complex relationship between running and the brain<b><\/b><\/h3>\n<p class=\"p1\">Some of the more sensational headlines claimed the brain \u201ceats itself.\u201d But the truth, as is often the case, is much more fascinating\u2014and far less catastrophic.<\/p>\n<p class=\"p1\">The team conducted MRI scans on the brains of ten amateur runners before, after, and up to two months following a marathon. In the immediate aftermath, myelin levels were reduced in certain areas tied to movement, sensory perception, and emotional processing\u2014unsurprisingly, the regions most activated during running. But within a few weeks, everything returned to normal.<\/p>\n<p class=\"p1\">This points to an extraordinary ability of the brain to adapt\u2014even in brains that aren\u2019t so young anymore: the participants ranged in age from 45 to 73. It\u2019s a reminder that neuroplasticity doesn\u2019t expire\u2014it just evolves.<\/p>\n<p class=\"p1\">As Matute notes, this discovery once again shows just how astonishingly adaptable and dynamic our brain is, even in adulthood.<\/p>\n<p class=\"p1\">In other words, while you\u2019re running yourself into exhaustion, your brain isn\u2019t just holding on\u2014it\u2019s transforming. Levels of dopamine, serotonin, and <a href=\"https:\/\/runlovers.it\/en\/2025\/the-endocannabinoid-system-the-secret-to-post-run-wellbeing\/\">endocannabinoids<\/a>\u2014the chemicals behind the famed \u201crunner\u2019s high\u201d\u2014all increase. Some studies have even observed enlargement of the hippocampus in marathon runners, the brain region linked to memory and learning.<\/p>\n<h3 class=\"p3\">The dark side of running: overtraining<b><\/b><\/h3>\n<p class=\"p1\">But every form of growth comes at a cost. Pushing the body\u2014and the brain\u2014too far can lead to overtraining syndrome. It often starts subtly, with mood shifts before performance drops. Irritability, fatigue, a sense of disorientation: the exact opposite of what you\u2019re chasing with your run.<\/p>\n<p class=\"p1\">In <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10409951\/\">a study<\/a>, Deakin University professor Luana Main and her team found that cognitive performance\u2014especially reaction time\u2014was impaired in athletes experiencing overload or overtraining. Main argues that when cognition is altered, people are more likely to make mistakes and get injured.<\/p>\n<p class=\"p1\">But that\u2019s not a reason to stop. If anything, it\u2019s a reason to learn to listen to yourself better. As Main suggests, subjective signals like mood and perceived stress are often more reliable than \u201cobjective\u201d metrics when it comes to knowing if you\u2019ve gone too far.<\/p>\n<p class=\"p1\">In short, your brain is far more than just a passenger on your run: it\u2019s a lead player\u2014adapting, changing, consuming, and rebuilding itself. As long as you treat it with respect.<\/p>\n<p class=\"p1\">When asked if running still makes sense, Matute replies calmly: \u201cYes, always. Just train smart.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>During a marathon, your brain might burn through its own myelin reserves just to get you across the finish line. A surprising discovery that\u2019s reshaping the way we understand running and neuroscience.<\/p>\n","protected":false},"author":2,"featured_media":93251,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[15136],"tags":[],"class_list":{"0":"post-93252","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-news-en"},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Marathon and Mind: The Hidden Secret Between Neurons - Runlovers<\/title>\n<meta name=\"description\" content=\"What really happens to your brain when you run long distances\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/runlovers.it\/en\/2025\/marathon-and-mind-the-hidden-secret-between-neurons\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Marathon and Mind: The Hidden Secret Between Neurons\" \/>\n<meta property=\"og:description\" content=\"What really happens to your brain when you run long distances\" \/>\n<meta property=\"og:url\" content=\"https:\/\/runlovers.it\/en\/2025\/marathon-and-mind-the-hidden-secret-between-neurons\/\" \/>\n<meta property=\"og:site_name\" content=\"Runlovers\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/runlovers\/\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/martino.pietropoli\" \/>\n<meta property=\"article:published_time\" content=\"2025-05-28T15:17:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/i0.wp.com\/runlovers.it\/wp-content\/uploads\/2025\/05\/Runners-in-Motion-2.jpg?fit=1200%2C801&quality=75&ssl=1\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"801\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Martino Pietropoli\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@mpietropoli\" \/>\n<meta name=\"twitter:site\" content=\"@runlovers\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Martino Pietropoli\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/runlovers.it\\\/en\\\/2025\\\/marathon-and-mind-the-hidden-secret-between-neurons\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/runlovers.it\\\/en\\\/2025\\\/marathon-and-mind-the-hidden-secret-between-neurons\\\/\"},\"author\":{\"name\":\"Martino Pietropoli\",\"@id\":\"https:\\\/\\\/runlovers.it\\\/en\\\/#\\\/schema\\\/person\\\/fdf85f5941aa635ddea3e21ca97d4f53\"},\"headline\":\"Marathon and Mind: The Hidden Secret Between Neurons\",\"datePublished\":\"2025-05-28T15:17:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/runlovers.it\\\/en\\\/2025\\\/marathon-and-mind-the-hidden-secret-between-neurons\\\/\"},\"wordCount\":635,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/runlovers.it\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/runlovers.it\\\/en\\\/2025\\\/marathon-and-mind-the-hidden-secret-between-neurons\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/i0.wp.com\\\/runlovers.it\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/Runners-in-Motion-2.jpg?fit=1200%2C801&quality=75&ssl=1\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/runlovers.it\\\/en\\\/2025\\\/marathon-and-mind-the-hidden-secret-between-neurons\\\/#respond\"]}],\"copyrightYear\":\"2025\",\"copyrightHolder\":{\"@id\":\"https:\\\/\\\/runlovers.it\\\/#organization\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/runlovers.it\\\/en\\\/2025\\\/marathon-and-mind-the-hidden-secret-between-neurons\\\/\",\"url\":\"https:\\\/\\\/runlovers.it\\\/en\\\/2025\\\/marathon-and-mind-the-hidden-secret-between-neurons\\\/\",\"name\":\"Marathon and Mind: The Hidden Secret Between Neurons - 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